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A Water‐Soluble Polycarbonate With Dimethylamino Pendant Groups Prepared by Enzyme‐Catalyzed Ring‐Opening Polymerization
Author(s) -
Zhang Xiaojin,
Cai Mengmeng,
Zhong Zhenlin,
Zhuo Renxi
Publication year - 2012
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201100765
Subject(s) - polycarbonate , ring opening polymerization , triphosgene , monomer , polymer chemistry , catalysis , triethylamine , carbonate , polymerization , trimethylene carbonate , diol , chemistry , aminolysis , polymer , organic chemistry , phosgene
A water‐soluble polycarbonate with dimethylamino pendant groups, poly(2‐dimethylaminotrimethylene carbonate) (PDMATC), is synthesized and characterized. First, the six‐membered carbonate monomer, 2‐dimethylaminotrimethylene carbonate (DMATC), is prepared via the cyclization reaction of 2‐(dimethylamino)propane‐1,3‐diol with triphosgene in the presence of triethylamine. Although the attempted ring‐opening polymerization (ROP) of DMATC with Sn(Oct) 2 as a catalyst fails, the ROP of DMATC is successfully carried out with Novozym‐435 as a catalyst to give water‐soluble aliphatic polycarbonate PDMATC with low cytotoxicity and good degradability.