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Block Copolypeptides Prepared by N ‐Carboxyanhydride Ring‐Opening Polymerization
Author(s) -
Habraken Gijs J. M.,
Heise Andreas,
Thornton Paul. D.
Publication year - 2012
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201100730
Subject(s) - dispersity , polymerization , polymer chemistry , block (permutation group theory) , materials science , ring opening polymerization , polymer science , ring (chemistry) , chemistry , polymer , composite material , organic chemistry , mathematics , geometry
N‐Carboxyanhydride ring‐opening polymerization (NCA ROP) is a synthetically straightforward methodology to generate homopolypeptides. Extensive control over the polymerization permits the production of highly monodisperse synthetic polypeptides to a targeted molecular weight in the absence of unfavorable side reactions. Sequential NCA ROP permits the creation of block copolypeptides composed of individual polypeptide blocks boasting different functionalities, secondary structures, and desirable chemical properties. Consequently, a plethora of novel materials have been generated that have found wide‐range applicability. This review offers an insight into contemporary synthetic approaches toward NCA ROP before highlighting a number of block copolypeptide architectures generated.