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In Situ Hetero End‐Functionalized Polythiophene and Subsequent “Click” Chemistry With DNA
Author(s) -
Lee Jungkyu K.,
Ko Sangwon,
Bao Zhenan
Publication year - 2012
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201100686
Subject(s) - azide , click chemistry , polythiophene , conjugated system , biomolecule , polymer , polymerization , gel permeation chromatography , copolymer , polymer chemistry , chemistry , matrix assisted laser desorption/ionization , combinatorial chemistry , materials science , desorption , organic chemistry , conductive polymer , biochemistry , adsorption
It is demonstrated that bifunctionalized polythiophenes involving thiol and azide end‐functional groups can be synthesized by chain‐growth Suzuki‐Miyaura type polymerization. The bifunctionalized polythiophenes are successfully characterized by 1H NMR, gel permeation chromatography (GPC), and matrix‐assisted laser desorption ionization time‐of‐flight (MALDI‐TOF). Furthermore, the azide end‐group reacts with DNA via “click chemistry” to form a polythiophene/DNA hybrid structure, which is characterized by ESI‐MS. The described synthetic approaches will lead to the synthesis of novel multi‐block copolymers as well as biomolecule‐based conjugated polymer structures.