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pH‐Disintegrable Polyelectrolyte Multilayer‐Coated Mesoporous Silica Nanoparticles Exhibiting Triggered Co‐Release of Cisplatin and Model Drug Molecules
Author(s) -
Wan Xuejuan,
Zhang Guoying,
Liu Shiyong
Publication year - 2011
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201100198
Subject(s) - polyelectrolyte , methacrylamide , nanoparticle , mesoporous silica , cationic polymerization , monomer , materials science , polymer chemistry , chemical engineering , copolymer , mesoporous material , chemistry , nanotechnology , organic chemistry , polymer , acrylamide , catalysis , engineering
We report on the fabrication of pH‐disintegrable polyelectrolyte multilayer‐coated mesoporous silica nanoparticles (MSN) capable of triggered co‐release of cisplatin and model drug molecules. The outer polyelectrolyte multilayer was assembled from permanently cationic polyelectrolyte, poly(allyl amine hydrochloride) (PAH), and negatively charged polyelectrolyte, P(DMA‐ co ‐TPAMA), consisting of N , N ‐dimethylacrylamide (DMA) and 3,4,5,6‐tetrahydrophthalic anhydride‐functionalized N ‐(3‐aminopropyl)methacrylamide (TPAMA) monomer units, which exhibits pH‐induced charge conversion characteristics. Thus, the subtle alteration of solution pH from 7.4 to ≈5–6 can lead to the disintegration of outer polyelectrolyte multilayers, accompanied with the co‐release of cisplatin and RhB.