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Polymer Brushes Showing Non‐Fouling in Blood Plasma Challenge the Currently Accepted Design of Protein Resistant Surfaces
Author(s) -
RodriguezEmmenegger Cesar,
Brynda Eduard,
Riedel Tomas,
Houska Milan,
Šubr Vladimir,
Alles Aldo Bologna,
Hasan Erol,
Gautrot Julien E.,
Huck Wilhelm T. S.
Publication year - 2011
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201100189
Subject(s) - methacrylamide , biofouling , fouling , materials science , acrylamide , wetting , polymer , surface plasmon resonance , chemical engineering , surface modification , polymer chemistry , nanotechnology , copolymer , chemistry , membrane , composite material , nanoparticle , biochemistry , engineering
Ultra‐low‐fouling poly[ N ‐(2‐hydroxypropyl) methacrylamide] (poly(HPMA)) brushes have been synthesized for the first time. Similar to the so far only ultra‐low‐fouling surface, poly(carboxybetaine acrylamide), the level of blood plasma fouling was below the detection limit of surface plasmon resonance (SPR, 0.03 ng · cm −2 ) despite being a hydrogen bond donor and displaying a moderate wettability, thus challenging the currently accepted views for the design of antifouling properties. The antifouling properties were preserved even after two years of storage. To demonstrate the potential of poly(HPMA) brushes for the preparation of bioactive ultra‐low fouling surfaces a label‐free SPR immunosensor for detection of G Streptococcus was prepared.