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In vitro Evaluation of Hexagonal Polymeric Micelles in Macrophage Phagocytosis
Author(s) -
Tsai HsiehChih,
Chang CheHau,
Chiu YieChan,
Lin ShuianYin,
Lin ChePing,
Hsiue GingHo
Publication year - 2011
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201100157
Subject(s) - micelle , transmission electron microscopy , copolymer , phagocytosis , materials science , hexagonal crystal system , porphyrin , nanoscopic scale , hexagonal lattice , amphiphile , microscopy , in vitro , nanoparticle , electron microscope , hela , polymer , nanotechnology , biophysics , macrophage , chemistry , crystallography , organic chemistry , composite material , optics , biochemistry , biology , microbiology and biotechnology , physics , condensed matter physics , antiferromagnetism , aqueous solution
This paper develops a non‐spherical polymeric micelle using an amphiphilic block copolymer and a porphyrin crystalline structure. The nanoscale polymer micelles were characterized by transmission electron microscopy (TEM) and atomic force microscopy (AFM), revealing particle sizes of approximately 150 nm with a particular shape in the hexagonal lattice. The shape shows the selective uptake efficacy for the HeLa and macrophage cells, and inhibits phagocytosis against the macrophage.