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HPMA Based Amphiphilic Copolymers Mediate Central Nervous Effects of Domperidone
Author(s) -
Hemmelmann Mirjam,
Knoth Christiane,
Schmitt Ulrich,
Allmeroth Mareli,
Moderegger Dorothea,
Barz Matthias,
Koynov Kaloian,
Hiemke Christoph,
Rösch Frank,
Zentel Rudolf
Publication year - 2011
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201000810
Subject(s) - domperidone , amphiphile , copolymer , polymerization , chemistry , polymer chemistry , biophysics , organic chemistry , polymer , medicine , dopamine , biology
In this study we give evidence that domperidone encapsulated into amphiphilic p(HPMA)‐ co ‐p(laurylmethacrylate) (LMA) copolymer aggregates is able to cross the blood–brain barrier, since it affected motor behaviour in animals, which is a sensitive measure for CNS actions. Carefully designed copolymers based on the clinically approved p(HPMA) were selected and synthesized by a combination of controlled radical polymerization and post‐polymerization modification. The hydrodynamic radii ( R h ) of amphiphilic p(HPMA) ‐co ‐p(LMA) alone and loaded with domperidone were determined by fluorescence correlation spectroscopy.