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“Clip” and “Click” Chemistries Combination: Toward Easy PEGylation of Degradable Aliphatic Polyesters
Author(s) -
Freichels Hélène,
Pourcelle Vincent,
Le Duff Cécile S.,
MarchandBrynaert Jacqueline,
Jérôme Christine
Publication year - 2011
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201000803
Subject(s) - pegylation , polyester , click chemistry , polymer science , chemistry , polymer chemistry , organic chemistry , combinatorial chemistry , polyethylene glycol
α‐Methoxy‐ω‐alkyne poly(ethylene glycol) (PEG) was tagged with pendent N ‐hydroxy‐succinimidyl activated esters by photografting of a molecular clip. This easily synthesized heterofunctional PEG was found to be a versatile building block for (i) conjugation with an amino derivative and (ii) grafting to azido functional aliphatic polyesters backbone by Huisgen's 1,3‐dipolar cycloaddition. This original combination of “clip” and “click” reactions provides a versatile and straightforward pathway for the synthesis of functional amphiphilic and degradable copolymers valuable for biomedical applications such as in drug‐delivery.