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A Lipase‐Responsive Vehicle Using Amphipathic Polymer Synthesized with the Lipase as Catalyst
Author(s) -
Ge Jun,
Lu Diannan,
Yang Cheng,
Liu Zheng
Publication year - 2011
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201000746
Subject(s) - lipase , amphiphile , hydrolysis , polymer , aqueous solution , catalysis , chemistry , aqueous two phase system , organic chemistry , materials science , polymer chemistry , chemical engineering , enzyme , combinatorial chemistry , copolymer , engineering
We describe an enzyme‐responsive polymeric vehicle, which is of great interest in controlled drug delivery, biosensing, and other related areas. The polymer synthesized using lipase as catalyst in DMSO has a favorable molecular structure that is quickly hydrolyzed by lipase in aqueous phase, and allows a fast release of encapsulated molecules.