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Dual Stimuli‐Responsive Polymeric Micelles Exhibiting “AND” Logic Gate for Controlled Release of Adriamycin
Author(s) -
Wei Chuan,
Guo Jia,
Wang Changchun
Publication year - 2011
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201000708
Subject(s) - micelle , copolymer , conjugated system , hydrazone , materials science , polymer , controlled release , hydrazine (antidepressant) , chemistry , combinatorial chemistry , polymer chemistry , nanotechnology , organic chemistry , aqueous solution , biochemistry
A new controlled release polymer micelle was designed and synthesized based on the concept of the “AND” logic with two orthogonal molecular triggers, namely pH and reduction, for intracellular drug delivery. Specifically, a hydrazine functionalized PEO‐ b ‐PMAA block copolymer was used to attach adriamycin (ADR) through the formation of hydrazone, then the as‐prepared ADR‐conjugated block copolymer micelles could be crosslinked by dithiodiethanoic acid. ADR was found to release most efficiently under both the low pH and the reductive conditions. This smart device is therefore equipped with two triggers with the “AND” logic for the releasing action, which is suitable for more complicated physiological conditions because the “ON” state is only realized under the simultaneous presence of the dual signal stimuli.