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Highly Efficient Drug Delivery Nanosystem via L ‐Phenylalanine Triggering Based on Supramolecular Polymer Micelles
Author(s) -
Dong Haiqing,
Li Yongyong,
Wen Huiyun,
Xu Meng,
Liu Lijian,
Li Zhuoquan,
Guo Fangfang,
Shi Donglu
Publication year - 2011
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201000693
Subject(s) - phenylalanine , photosensitizer , cyclodextrin , micelle , photodynamic therapy , drug delivery , porphyrin , chemistry , supramolecular chemistry , combinatorial chemistry , polymer , controlled release , materials science , nanotechnology , organic chemistry , biochemistry , amino acid , molecule , aqueous solution
An intelligent drug delivery nanosystem has been developed based on biodegradable supramolecular polymer micelles (SMPMs). The drug release can be triggered from SMPMs responsively by a bioactive agent, L ‐phenylalanine in a controlled fashion. The SMPMs are constructed from ethylcellulose‐ graft ‐poly( ε ‐caprolactone) (EC‐ g ‐PCL) and α‐cyclodextrin (α‐CD) derivate via host–guest and hydrophobic interactions. It has been found that these SMPMs have disassembled rapidly in response to an additional L ‐phenylalanine, due to great affinity discrepancy to α‐CD between L ‐phenylalanine and PCL. Experiments have been carried out on trigger‐controlled in vitro drug release of the SMPMs loaded with a model porphyrin based photosensitizer THPP. The result shows that the SMPMs released over 85% THPP in 6 h, which is two orders magnitudes faster than that of control. Also investigated is the photodynamic therapy (PDT) of THPP‐loaded SMPMs with and without L ‐phenylalanine on MCF‐7 carcinoma cell line. An effective trigger‐concentration dependent lethal effect has been found showing promise in clinical photodynamic therapy.