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Molecularly Imprinted Nanospheres by Nonaqueous Emulsion Polymerization
Author(s) -
Dvorakova Gita,
Haschick Robert,
Chiad Khalid,
Klapper Markus,
Müllen Klaus,
Biffis Andrea
Publication year - 2010
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201000406
Subject(s) - methacrylic acid , dispersity , emulsion polymerization , precipitation polymerization , molecularly imprinted polymer , polymerization , polymer , chemical engineering , emulsion , pickering emulsion , monomer , materials science , polymer chemistry , molecular imprinting , chemistry , radical polymerization , organic chemistry , catalysis , selectivity , engineering
The preparation of nanosized, molecularly imprinted polymer particles by nonaqueous emulsion polymerization is presented. Monodisperse cross‐linked polymer nanospheres with a diameter of around 100 nm were synthesized using a standard monomer mixture of methacrylic acid and ethylene dimethacrylate, containing (±)‐propranolol as a template. The rebinding efficiency of the resulting particles was determined by batch rebinding tests and isothermal titration calorimetry (ITC). The results indicate that the proposed imprinting process under nonaqueous conditions lead to particles with an enhanced capacity of template rebinding compared to both nonimprinted ones and to particles obtained by more conventional emulsion polymerization in water.