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Labeled Nanoparticles Based on Pharmaceutical EUDRAGIT® S 100 Polymers
Author(s) -
Vollrath Antje,
Schubert Stephanie,
Windhab Norbert,
Biskup Christoph,
Schubert Ulrich S.
Publication year - 2010
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201000373
Subject(s) - polymer , nanocarriers , nanoparticle , drug delivery , covalent bond , biocompatibility , materials science , drug carrier , chemistry , copolymer , fluorescence , chemical engineering , polymer chemistry , nanotechnology , organic chemistry , physics , quantum mechanics , engineering
The pharmaceutically important polymer P(MAA– r –MMA) 1:2 (EUDRAGIT ® S100) was investigated concerning its behavior to form nanoparticles via nanoprecipitation. The particles obtained were characterized regarding their size, shape, and characteristics using DLS, SEM, and AUC. Furthermore, the P(MAA– r –MMA) 1:2 copolymer was modified with different markers in order to achieve polymer‐based nanocarrier systems, which are detectable and may be useful for controlled drug delivery devices to monitor the drug pathways. The particles were labeled by physical entrapment as well as by covalent attachment of various markers, e.g., radicals, fluorescent‐, and near‐infrared dyes, to the polymer. Physical entrapment of radicals into the polymeric units was performed by co‐nanoprecipitation of P(MAA– r –MMA) 1:2 and a radical marker. By means of covalent binding of the markers to the polymer, a stable and more defined labeling of the particles was also performed, leading only to a low degree of modification of the pharmaceutical polymer. After nanoprecipitation, the resulting labeled particles were characterized by SEM and DLS, whereas their biocompatibility was proven by in vitro studies. In order to ensure the possibility of detection of the particles inside the body for drug delivery‐, sensor‐, and imaging applications, the polymeric carriers were also investigated by electron spin resonance, fluorescence, as well as near‐infrared spectroscopy.