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Multifunctional Poly(2‐oxazoline) Nanoparticles for Biological Applications
Author(s) -
Kempe Kristian,
Vollrath Antje,
Schaefer Hendrik W.,
Poehlmann Tobias G.,
Biskup Christoph,
Hoogenboom Richard,
Hornig Stephanie,
Schubert Ulrich S.
Publication year - 2010
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201000283
Subject(s) - nanoparticle , covalent bond , oxazoline , polymer , materials science , confocal microscopy , polymer chemistry , fluorescein , confocal , click chemistry , nanotechnology , chemical engineering , chemistry , fluorescence , organic chemistry , optics , physics , composite material , catalysis , engineering
New multifunctional copoly(2‐oxazoline) nanoparticles were prepared for cell studies. The polymer contains double‐bond side chains as potential reaction sites for “thio”‐click reactions as well as a fluorescein label covalently bound to the polymer backbone. Using the nanoprecipitation technique, spherical nanoparticles of 200–800 nm were obtained. Confocal laser scanning microscopy measurements revealed the cellular uptake of the nanoparticles.