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Biomimetic Mussel Adhesive Inspired Clickable Anchors Applied to the Functionalization of Fe 3 O 4 Nanoparticles
Author(s) -
Goldmann Anja S.,
Schödel Christine,
Walther Andreas,
Yuan Jiayin,
Loos Katja,
Müller Axel H. E.
Publication year - 2010
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201000193
Subject(s) - surface modification , click chemistry , nanoparticle , ethylene glycol , alkyne , catechol , covalent bond , rhodamine , iron oxide nanoparticles , rhodamine b , materials science , combinatorial chemistry , chemistry , polymer chemistry , nanotechnology , fluorescence , organic chemistry , quantum mechanics , physics , photocatalysis , catalysis
The functionalization of magnetite (Fe 3 O 4 ) nanoparticles with dopamine‐derived clickable biomimetic anchors is reported. Herein, an alkyne‐modified catechol‐derivative is employed as the anchor, as i) the catechol‐functional anchor groups possess irreversible covalent binding affinity to Fe 3 O 4 nanoparticles, and ii) the alkyne terminus enables further functionalization of the nanoparticles by the grafting‐onto approach with various possibilities offered by ‘click’ chemistry. In the present work, azido‐end group functionalized Rhodamine and poly(ethylene glycol) (PEG) are utilized to coat the iron oxide nanoparticles to make them fluorescent and water soluble.