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Tailored Albumin‐based Copolymers for Receptor‐Mediated Delivery of Perylenediimide Guest Molecules
Author(s) -
Eisele Klaus,
Gropeanu Radu,
Musante Ashlan,
Glasser Gunnar,
Li Chen,
Muellen Klaus,
Weil Tanja
Publication year - 2010
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201000176
Subject(s) - endocytosis , copolymer , folate receptor , chemistry , micelle , receptor mediated endocytosis , molecule , human serum albumin , drug delivery , albumin , combinatorial chemistry , vesicle , biophysics , drug carrier , receptor , membrane , polymer chemistry , biochemistry , organic chemistry , cancer cell , polymer , biology , cancer , aqueous solution , genetics
The synthesis of a novel and multifunctional copolymer based on a human serum albumin backbone bearing several folic acid as well as PEO groups was presented. In solution, this side‐chain copolymer adopts a globular architecture and about five molecules of the water‐insoluble chromophore PDI were successfully incorporated into these micelles for receptor‐mediated cell uptake investigations. A significant uptake of these bioconjugates via receptor‐mediated endocytosis was detected for cells expressing folic acid receptors in the cell membrane. These novel albumin‐based copolymers could serve as efficient and biocompatible carrier systems facilitating the directed delivery of lipophilic drug molecules into cancer cells and they allow investigating vesicle formation and trafficking even at the single molecule level.