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Effect of Coordination on the Glucose‐Responsiveness of PEG‐ b ‐(PAA‐ co ‐PAAPBA) Micelles
Author(s) -
Wang Beilei,
Ma Rujiang,
Liu Gan,
Liu Xiaojun,
Gao Yaohua,
Shen Junyang,
An Yingli,
Shi Linqi
Publication year - 2010
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201000164
Subject(s) - micelle , peg ratio , acrylic acid , copolymer , ethylene glycol , polymer chemistry , boron , chemistry , magic angle spinning , polyethylene glycol , amphiphile , materials science , nuclear chemistry , aqueous solution , nuclear magnetic resonance spectroscopy , stereochemistry , organic chemistry , polymer , finance , economics
Poly(ethylene glycol)‐ block ‐poly(acrylic acid) (PEG‐PAA) is modified by 3‐aminophenylboronic acid (APBA) with different modification degrees, such as PEG 114 ‐ b ‐(PAA 0.37 ‐ co ‐PAAPBA 0.63 ) 170 , PEG 114 ‐ b ‐(PAA 0.23 ‐ co ‐PAAPBA 0.77 ) 170 and PEG 114 ‐ b ‐(PAA 0.02 ‐ co ‐PAAPBA 0.98 ) 170 . Micelles self‐assembled from these three copolymers possess glucose‐responsiveness at varying pH values. Micelles self‐assembled from PEG 114 ‐ b ‐(PAA 0.37 ‐ co ‐PAAPBA 0.63 ) 170 have glucose‐responsiveness at the physiological pH (7.4), endowing them with potential applications in the treatment of diabetes. 11 B magic‐angle spinning nuclear magnetic resonance ( 11 B MAS NMR) analysis indicates that interactions between PAAPBA segments and PAA segments induce boron changes from the trigonal planar form to the tetrahedral form, resulting in glucose‐responsiveness of PEG 114 ‐ b ‐(PAA 0.37 ‐ co ‐PAAPBA 0.63 ) 170 micelles at pH 7.4.
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