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Modular StarPEG‐Heparin Gels with Bifunctional Peptide Linkers
Author(s) -
Tsurkan Mikhail V.,
Chwalek Karolina,
Levental Kandice R.,
Freudenberg Uwe,
Werner Carsten
Publication year - 2010
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201000155
Subject(s) - self healing hydrogels , peptide , heparin , ethylene glycol , bifunctional , matrix metalloproteinase , growth factor , materials science , adhesive , matrix (chemical analysis) , chemistry , biophysics , nanotechnology , polymer chemistry , biochemistry , organic chemistry , biology , chromatography , layer (electronics) , receptor , catalysis
Cell responsive materials are instrumental to regenerative therapies. Here, we report about a novel biohybrid hydrogel that consists of heparin and peptide‐conjugated star‐shaped poly(ethylene glycol), crosslinked by peptide units that combine matrix metalloproteinase (MMP) sensitivity and cell adhesive modules. Taking advantage of the high affinity of vascular endothelial growth factor to heparin, we illustrate the applicability of our hydrogels as a novel system that is supportive of cellular remodeling and three‐dimensional migration of human endothelial cells.