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Supramolecular Aggregates of Water Soluble Dendritic Polyglycerol Architectures for the Solubilization of Hydrophobic Compounds
Author(s) -
Kurniasih Indah N.,
Liang Hua,
Rabe Jürgen P.,
Haag Rainer
Publication year - 2010
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201000112
Subject(s) - nile red , amphiphile , pyrene , supramolecular chemistry , dendrimer , chemistry , polymer chemistry , hydrophobe , hydrophobic effect , macromolecule , chemical engineering , polymer , organic chemistry , molecule , copolymer , fluorescence , biochemistry , physics , quantum mechanics , engineering
Abstract Dendritic core–shell architectures which are based on hyperbranched polyglycerol for the solubilization of hydrophobic drugs have been synthesized and characterized. The core of hyperbranched polyglycerol has been modified with hydrophobic biphenyl groups or perfluorinated chains to increase the core hydrophobicity of the macromolecules. These amphiphilic core–shell type architectures were then used to solubilize pyrene, nile red, and a perfluoro tagged diazo dye, as well as the drug nimodipine in water. Specific host–guest interactions such as fluorous–fluorous interactions could be tailored by this flexible core design and determined by UV spectroscopy. The transport capacity increased 450‐fold for nile red, 47‐fold for nimodipine, and 37‐fold for pyrene at a polymer concentration of only 0.1 wt.‐%. Surface tension measurements and scanning force microscopy (SFM) were used to reveal the aggregation properties of these complexes. The formation of supramolecular aggregates with diameters of ≈20 nm and critical aggregate concentrations of 2 × 10 −6 mol · L −1 have been observed. This indicates the controlled self‐assembly of the presented amphiphilic dendritic core–shell type architectures.