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Glucosamine Hydrochloride Functionalized Water‐Soluble Conjugated Polyfluorene: Synthesis, Characterization, and Interactions with DNA
Author(s) -
Chen Qi,
Cheng QianYi,
Zhao YanChao,
Han BaoHang
Publication year - 2009
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200900226
Subject(s) - polyfluorene , conjugated system , biocompatibility , polymer chemistry , polymer , hydrochloride , chitosan , polymerization , grafting , materials science , chemistry , combinatorial chemistry , organic chemistry
Novel glucosamine hydrochloride functionalized water‐soluble conjugated polyfluorene was easily synthesized through Cu(I)‐catalyzed azide/alkyne “click” ligation and Suzuki coupling polymerization. The water‐solubility and biocompatibility of the polymer were improved after grafting glucosamine hydrochloride to the side chains of the conjugated polymer. As a fluorescent model system of chitosan, its interaction with single‐stranded DNA was studied by spectrofluorometric titration.