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Synthesis of Folic Acid Functionalized PLLA‐ b ‐PPEGMA Nanoparticles for Cancer Cell Targeting
Author(s) -
Hu Feixiong,
Neoh Koon Gee,
Kang EnTang
Publication year - 2009
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200800771
Subject(s) - ethylene glycol , atom transfer radical polymerization , nanoparticle , polymer chemistry , solvent , chemistry , polymerization , materials science , combinatorial chemistry , polymer , organic chemistry , nanotechnology
Poly( L ‐lactic acid)‐ block ‐poly(poly(ethylene glycol) monomethacrylate) (PLLA‐ b ‐PPEGMA) has been prepared by the ring‐opening polymerization of lactide with a double‐headed initiator, 2‐hydroxyethyl 2′‐methyl‐2′‐bromopropionate (HMBP), followed by atom transfer radical polymerization (ATRP) of poly(ethylene glycol) monomethacrylate (PEGMA). PLLA‐ b ‐PPEGMA nanoparticles with encapsulated Fe 3 O 4 are prepared by a solvent evaporation/extraction technique, and then further functionalized with folic acid, a cancer targeting ligand. Our results show that such functionalized PLLA‐ b ‐PPEGMA nanoparticles have good potential as carriers for targeted drug delivery in cancer treatment.