Kinetics of Core‐Shell Nanoparticle Formation by Two‐Dimensional Nuclear Magnetic Resonance

We have studied the kinetics of polymeric nanoparticle formation for poly(styrene‐ block ‐4‐vinylpyridine) [P(S‐ b ‐4‐VPy)], chains in a non‐selective solvent using 1,4‐dibromobutane (DBB) as a cross‐linker by means of different nuclear magnetic resonance (NMR) spectroscopy techniques. The kinetic process was followed using 1 H, 13 C, and 2‐D Heteronuclear Single Quantum Correlation (HSQC) NMR experiments. The kinetic data obtained from 2‐D HSQC and 1 H NMR experiments were in good agreement between them, proving the reliability of the 2‐D HSQC NMR technique for the in situ study of the kinetics of core‐shell nanoparticle formation. A value of 1.5 × 10 −5 s −1 was determined for the apparent kinetic constant of the P(S‐ b ‐4‐VPy)‐DBB core‐shell nanoparticle formation process.