Nonfouling Polypeptide Brushes via Surface‐initiated Polymerization of  N   ε  ‐oligo(ethylene glycol)succinate‐ L ‐lysine  N ‐carboxyanhydride | Zendy

Wang Jing | Zendy; Gibson Matthew I. | Zendy; Barbey Raphaël | Zendy; Xiao ShouJun | Zendy; Klok HarmAnton | Zendy

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Nonfouling Polypeptide Brushes via Surface‐initiated Polymerization of N ε ‐oligo(ethylene glycol)succinate‐ L ‐lysine N ‐carboxyanhydride

Author(s) -

Wang Jing,

Gibson Matthew I.,

Barbey Raphaël,

Xiao ShouJun,

Klok HarmAnton

Publication year - 2009

Publication title -

macromolecular rapid communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.348

H-Index - 154

eISSN - 1521-3927

pISSN - 1022-1336

DOI - 10.1002/marc.200800744

Subject(s) - ethylene glycol , polymer chemistry , polymerization , chemistry , lower critical solution temperature , lysine , ethylene , polymer , copolymer , materials science , organic chemistry , catalysis , biochemistry , amino acid

This contribution describes the preparation of nonfouling polypeptide brushes via surface‐initiated ring‐opening polymerization of oligo(ethylene glycol) modified L ‐lysine N ‐carboxyanhydrides. Circular dichroism experiments indicated that these surface‐anchored polypeptide chains assume an α ‐helical conformation, which does not change between pH 4 and 9. Furthermore, nonspecific adsorption of fluorescent labeled bovine serum albumin and fibrinogen on glass slides modified with these brushes was greatly reduced compared to unmodified glass substrates.

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