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Nonfouling Polypeptide Brushes via Surface‐initiated Polymerization of N ε ‐oligo(ethylene glycol)succinate‐ L ‐lysine N ‐carboxyanhydride
Author(s) -
Wang Jing,
Gibson Matthew I.,
Barbey Raphaël,
Xiao ShouJun,
Klok HarmAnton
Publication year - 2009
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200800744
Subject(s) - ethylene glycol , polymer chemistry , polymerization , chemistry , lower critical solution temperature , lysine , ethylene , polymer , copolymer , materials science , organic chemistry , catalysis , biochemistry , amino acid
Abstract This contribution describes the preparation of nonfouling polypeptide brushes via surface‐initiated ring‐opening polymerization of oligo(ethylene glycol) modified L ‐lysine N ‐carboxyanhydrides. Circular dichroism experiments indicated that these surface‐anchored polypeptide chains assume an α ‐helical conformation, which does not change between pH 4 and 9. Furthermore, nonspecific adsorption of fluorescent labeled bovine serum albumin and fibrinogen on glass slides modified with these brushes was greatly reduced compared to unmodified glass substrates.