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Electrospinning of Collagen Nanofiber Scaffolds from Benign Solvents
Author(s) -
Dong Bin,
Arnoult Olivier,
Smith Meghan E.,
Wnek Gary E.
Publication year - 2009
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200800634
Subject(s) - electrospinning , nanofiber , materials science , chemical engineering , dissolution , polymer chemistry , solvent , phosphate buffered saline , fourier transform infrared spectroscopy , chemistry , composite material , polymer , chromatography , organic chemistry , engineering
Nanofiber scaffolds of collagen have been fabricated via electrospinning using benign solvent systems as a replacement for 1,1,1,3,3,3 hexafluoro‐2‐propanol. Simple binary mixtures of phosphate‐buffered saline and ethanol have been found to be highly effective for electrospinning. FTIR spectra suggest that the triple helical structure of collagen was conserved after dissolution and electrospinning. Crosslinking of the electrospun collagen scaffolds was achieved with standard methods.