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Synthesis of Seven‐Arm Poly(vinyl pyrrolidone) Star Polymers with Lysozyme Core Prepared by MADIX/RAFT Polymerization
Author(s) -
McDowall Lyndall,
Chen Gaojian,
Stenzel Martina H.
Publication year - 2008
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200800416
Subject(s) - lysozyme , polymer chemistry , polymer , raft , polymerization , chemistry , reversible addition−fragmentation chain transfer polymerization , materials science , radical polymerization , organic chemistry , biochemistry
A poly(vinyl pyrrolidone) (PVP) seven‐arms star polymer with lysozyme core was synthesized by conjugating linear N ‐succinimidyl ester terminated PVP polymer to lysozyme. Reactive PVP polymers were synthesized using a MADIX/RAFT agent functionalized with N ‐succinimidyl ester. The polymerization of N ‐vinyl pyrrolidone proceeded in a living fashion up to more than 90% conversion reaching molecular weight of up to 33 000 g · mol −1 with narrow molecular weight distributions. The PVP polymer was conjugated to lysozyme resulting in the attachment of seven PVP polymers to one lysozyme core. While the reaction was found to be complete when using low‐molecular weight PVP, some by‐products with less than seven arms were observed when using PVP with a molecular weight of 33 000 g · mol −1 .