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Click Chemistry: A Powerful Tool to Create Polymer‐Based Macromolecular Chimeras
Author(s) -
Le Droumaguet Benjamin,
Velonia Kelly
Publication year - 2008
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200800155
Subject(s) - click chemistry , macromolecule , nanotechnology , merge (version control) , chemistry , synthetic polymer , nucleic acid , polymer , synthetic biology , chemical biology , nanoreactor , polymer science , combinatorial chemistry , materials science , computer science , computational biology , organic chemistry , biochemistry , biology , nanoparticle , information retrieval
The combination of polymeric with biological materials, to create biohybrid macromolecules that merge the properties of both the natural and synthetic components, is a flourishing area in both life sciences and biotechnology. The click chemistry philosophy has recently provided a powerful tool in this direction, leading to a plethora of novel, tailor‐made biomacromolecules with unprecedented structural characteristics and properties. The different synthetic strategies, using the alkyne–azide click cycloadditions to bioorthogonally achieve the coupling of synthetic polymers with nucleic acids, peptides, sugars, proteins or even viruses and cells is described. The review covers the latest developments in this very dynamic and rapidly expanding field.