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Sonochemical Synthesis of Magnetic Protein Container for Targeted Delivery
Author(s) -
Han Yongsheng,
Radziuk Darya,
Shchukin Dmitry,
Moehwald Helmuth
Publication year - 2008
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200800105
Subject(s) - zeta potential , sonication , dissolution , drug delivery , chemical engineering , materials science , nanotechnology , deposition (geology) , layer (electronics) , targeted drug delivery , magnetic nanoparticles , chemistry , chromatography , nanoparticle , engineering , paleontology , sediment , biology
A new targeted delivery system was developed in this paper by depositing magnetic NPs on protein containers which were prepared by sonicating oil in a protein solution. The deposition was conducted by layer‐by‐layer technique and monitored by zeta potential measurement. Such prepared samples can be targeted delivery in an external magnetic field. The hydrophobic dye TPP, as a model of drug, was loaded in the containers by dissolution in the oil phase before sonication. The containers loaded with dye are stable and can sustain the deposition treatment without loss of dye due to the protection of protein nanoshells.