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Direct Generation of Polymer Films on Copper Surfaces through Azide‐Alkyne Cycloaddition Reactions between Peptidomimetic Oligomers
Author(s) -
Shah Neel H.,
Kirshenbaum Kent
Publication year - 2008
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200800042
Subject(s) - oligomer , cycloaddition , peptidomimetic , polymer , alkyne , copper , azide , polymer chemistry , materials science , macromolecule , chemistry , combinatorial chemistry , organic chemistry , peptide , catalysis , biochemistry
N ‐substituted glycine oligomers, or peptoids, can be used in conjunction with the copper‐catalyzed [3 + 2] cycloaddition of azides and alkynes to generate branched polymer networks. By incorporating both azides and alkynes as side chain functionalities on the oligomer scaffolds, peptoids are able to form cross‐linked macromolecular products. The oligomer starting materials are readily associated onto copper metal sheets, allowing for localized cross‐link proliferation which in turn generates thin film polymer coatings. This novel procedure provides a direct method for the chemical modification of metal surfaces and the formation of mechanically robust sequence‐specific polymer networks.