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Novel Amphiphilic Degradable Poly( ε ‐caprolactone)‐ graft ‐poly(4‐vinyl pyridine), Poly( ε ‐caprolactone)‐ graft ‐poly(dimethylaminoethyl methacrylate) and Water‐Soluble Derivatives
Author(s) -
Nottelet Benjamin,
Vert Michel,
Coudane Jean
Publication year - 2008
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200800037
Subject(s) - polymer chemistry , copolymer , amphiphile , caprolactone , monomer , methacrylate , cationic polymerization , ethylene glycol , grafting , polymerization , materials science , peg ratio , chemistry , polymer , organic chemistry , finance , economics
Abstract New amphiphilic graft copolymers that have a poly( ε ‐caprolactone) (PCL) biodegradable hydrophobic backbone and poly(4‐vinylpyridine) (P4VP) or poly(2‐( N , N‐ dimethylamino)ethyl methacrylate) (PDMAEMA) hydrophilic side chains have been prepared by anionic polymerization of the corresponding 4VP and DMAEMA monomers using a PCL‐based macropolycarbanion as initiator. The water solubility of these amphiphilic copolymers is improved by quaternization, which leads to fully water‐soluble cationic copolymers that give micellar aggregates in deionized water with diameters ranging from 65 to 125 nm. In addition, to improve the hydrophilicity of PCL‐ g ‐P4VP, grafting of poly(ethylene glycol) (PEG) segments has been carried out to give a water‐soluble double grafted PCL‐ g ‐(P4VP;PEG) terpolymer.