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Cellular Uptake of DNA Block Copolymer Micelles with Different Shapes
Author(s) -
Alemdaroglu Fikri E.,
Alemdaroglu N. Ceren,
Langguth Peter,
Herrmann Andreas
Publication year - 2008
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200700779
Subject(s) - micelle , internalization , copolymer , dna , cytotoxicity , biophysics , chemistry , critical micelle concentration , chemical engineering , materials science , polymer chemistry , cell , organic chemistry , biochemistry , polymer , in vitro , aqueous solution , biology , engineering
The cellular uptake of DNA block copolymer micelles composed of DNA‐ b ‐PPO in Caco‐2 cells was studied. In particular it was investigated if the shape of micelle aggregates influences the internalization. Rod‐like polymeric particles were taken up 12 times more efficiently than their spherical counter parts although they were composed of the same constituents. Furthermore, it was observed that internalization of all the micelle systems was more efficient than the pristine DNA controls. A cytotoxicity assay proved the non‐toxic nature of DNA‐ b ‐PPO micelle aggregates.