Synthesis of Peptide/Polymer Conjugates by Solution ATRP of Butylacrylate Using an Initiator‐Modified Cyclic  D ‐ alt ‐ L ‐Peptide | Zendy

Loschonsky Sidar | Zendy; Couet Julien | Zendy; Biesalski Markus | Zendy

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Synthesis of Peptide/Polymer Conjugates by Solution ATRP of Butylacrylate Using an Initiator‐Modified Cyclic D ‐ alt ‐ L ‐Peptide

Author(s) -

Loschonsky Sidar,

Couet Julien,

Biesalski Markus

Publication year - 2008

Publication title -

macromolecular rapid communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.348

H-Index - 154

eISSN - 1521-3927

pISSN - 1022-1336

DOI - 10.1002/marc.200700700

Subject(s) - peptide , molecule , molar mass , conjugate , polymer , chemistry , polymer chemistry , cyclic peptide , copolymer , covalent bond , self assembly , materials science , combinatorial chemistry , organic chemistry , biochemistry , mathematical analysis , mathematics

Peptide/polymer hybrid molecules consisting of poly(butylacrylate) chains, covalently attached to a cyclic D ‐ alt ‐ L ‐octapeptide, were prepared by the in situ ATRP of butylacrylate using a cyclic peptide that was modified at three distinct positions with an initiator group. The apparent molar mass of the peptide/PBA hybrid molecules could be controlled through adjusting the reaction conversion. The hybrid molecule showed a solvent induced self‐assembly, which yielded rod‐like nanostructures having a core shell morphology with an internal beta‐sheet peptide assembly surrounded by a soft PBA exterior.

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