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Synthesis of Peptide/Polymer Conjugates by Solution ATRP of Butylacrylate Using an Initiator‐Modified Cyclic D ‐ alt ‐ L ‐Peptide
Author(s) -
Loschonsky Sidar,
Couet Julien,
Biesalski Markus
Publication year - 2008
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200700700
Subject(s) - peptide , molecule , molar mass , conjugate , polymer , chemistry , polymer chemistry , cyclic peptide , copolymer , covalent bond , self assembly , materials science , combinatorial chemistry , organic chemistry , biochemistry , mathematical analysis , mathematics
Peptide/polymer hybrid molecules consisting of poly(butylacrylate) chains, covalently attached to a cyclic D ‐ alt ‐ L ‐octapeptide, were prepared by the in situ ATRP of butylacrylate using a cyclic peptide that was modified at three distinct positions with an initiator group. The apparent molar mass of the peptide/PBA hybrid molecules could be controlled through adjusting the reaction conversion. The hybrid molecule showed a solvent induced self‐assembly, which yielded rod‐like nanostructures having a core shell morphology with an internal beta‐sheet peptide assembly surrounded by a soft PBA exterior.