Acid‐Degradable Core‐Crosslinked Micelles Prepared from Thermosensitive Glycopolymers Synthesized via RAFT Polymerization | Zendy

Zhang Ling | Zendy; Bernard Julien | Zendy; Davis Thomas P. | Zendy; BarnerKowollik Christopher | Zendy; Stenzel Martina H. | Zendy

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Acid‐Degradable Core‐Crosslinked Micelles Prepared from Thermosensitive Glycopolymers Synthesized via RAFT Polymerization

Author(s) -

Zhang Ling,

Bernard Julien,

Davis Thomas P.,

BarnerKowollik Christopher,

Stenzel Martina H.

Publication year - 2008

Publication title -

macromolecular rapid communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.348

H-Index - 154

eISSN - 1521-3927

pISSN - 1022-1336

DOI - 10.1002/marc.200700663

Subject(s) - glycopolymer , copolymer , micelle , polymer chemistry , polymerization , raft , reversible addition−fragmentation chain transfer polymerization , chain transfer , acrylic acid , hydrolysis , materials science , aqueous solution , chemistry , radical polymerization , polymer , organic chemistry

A thermoresponsive block copolymer, namely poly(acryloyl glucosamine)‐ block ‐poly( N ‐isopropylacryamide) (PAGA 180 ‐ b ‐PNIPAAM 350 ) was simultaneously self‐assembled and crosslinked in aqueous medium via RAFT polymerization at 60 °C to afford core‐crosslinked micelles exhibiting a glycopolymer corona and a PNIPAAM stimuli‐responsive core. An acid‐labile crosslinking agent, 3,9‐divinyl‐2,4,8,10‐tetraoxaspiro[5.5]undecane, was employed to generate thermosensitive and acid‐degradable core‐shell nanoparticles. Stable against degradation at pH = 6 and 8.2, the resulting core crosslinked micelles readily hydrolyzed into well‐defined free block copolymers at lower pH (30 min and 12 h respectively at pH = 2 and 4).

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