Premium
Acid‐Degradable Core‐Crosslinked Micelles Prepared from Thermosensitive Glycopolymers Synthesized via RAFT Polymerization
Author(s) -
Zhang Ling,
Bernard Julien,
Davis Thomas P.,
BarnerKowollik Christopher,
Stenzel Martina H.
Publication year - 2008
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200700663
Subject(s) - glycopolymer , copolymer , micelle , polymer chemistry , polymerization , raft , reversible addition−fragmentation chain transfer polymerization , chain transfer , acrylic acid , hydrolysis , materials science , aqueous solution , chemistry , radical polymerization , polymer , organic chemistry
A thermoresponsive block copolymer, namely poly(acryloyl glucosamine)‐ block ‐poly( N ‐isopropylacryamide) (PAGA 180 ‐ b ‐PNIPAAM 350 ) was simultaneously self‐assembled and crosslinked in aqueous medium via RAFT polymerization at 60 °C to afford core‐crosslinked micelles exhibiting a glycopolymer corona and a PNIPAAM stimuli‐responsive core. An acid‐labile crosslinking agent, 3,9‐divinyl‐2,4,8,10‐tetraoxaspiro[5.5]undecane, was employed to generate thermosensitive and acid‐degradable core‐shell nanoparticles. Stable against degradation at pH = 6 and 8.2, the resulting core crosslinked micelles readily hydrolyzed into well‐defined free block copolymers at lower pH (30 min and 12 h respectively at pH = 2 and 4).