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Synthesis of Polyelectrolytes Bearing Phosphorylcholine Moieties
Author(s) -
Reisch Andreas,
Voegel JeanClaude,
Decher Gero,
Schaaf Pierre,
Mésini Philippe J.
Publication year - 2007
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200700510
Subject(s) - polyelectrolyte , phosphorylcholine , acrylic acid , side chain , polymer chemistry , amine gas treating , lysine , chemistry , materials science , organic chemistry , amino acid , copolymer , polymer , biochemistry
We report on the modification of the polyelectrolytes poly( L ‐glutamic acid) (PGA), poly(acrylic acid) (PAA), and poly( L ‐lysine) (PLL) with side groups bearing phosphorylcholine (PC) groups. Two different side chains were synthesized from monoamino tri‐ or tetraethylene glycol, both with PC group linked to the OH end: the tert ‐butyloxycarbonyl protected compounds BOCNH(EO) n PC ( n = 2, 3) and the succinylated compound SucNH(EO) 3 PC. BOCNH(EO) n PC was deprotected and the resulting amine was condensed with PGA or PAA and SucNH(EO) 3 PC was directly coupled to PLL. Degrees of substitution as high as 80% were obtained with the method described. These polyelectrolytes are potential candidates to fabricate multilayers with protein repellent properties.