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Stable Aqueous Dispersion of PEGylated Nanoparticles by Polyelectrolyte Complex Formation
Author(s) -
Paneva Dilyana,
Mespouille Laetitia,
Bougard François,
Manolova Nevena,
Degée Philippe,
Rashkov Iliya,
Dubois Philippe
Publication year - 2007
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200700079
Subject(s) - atom transfer radical polymerization , polyelectrolyte , ethylene glycol , copolymer , dynamic light scattering , polymer chemistry , materials science , aqueous solution , nanoparticle , methacrylate , chemical engineering , polymerization , polymer , chemistry , nanotechnology , organic chemistry , engineering , composite material
Stable aqueous dispersions of nanoparticles were prepared by polyelectrolyte complex formation between well‐defined poly(ethylene glycol)‐ block ‐poly(2‐acrylamido‐2‐methyl‐1‐propane sodium sulfonate) and poly(ethylene glycol)‐ block ‐poly[2‐(dimethylamino)ethyl methacrylate] diblock copolymers. Controlled synthesis of the copolymers was achieved by water‐based atom transfer radical polymerization (ATRP). The nanoparticles were characterized by a quite narrow and monomodal size distribution as evidenced by dynamic light scattering (DLS) and confirmed by atomic force microscopy (AFM) after solution casting and freeze‐drying.