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Novel Acid‐Labile, Thermoresponsive Poly(methacrylamide)s with Pendent Ortho Ester Moieties
Author(s) -
Huang Xiaonan,
Du Fusheng,
Ju Rong,
Li Zichen
Publication year - 2007
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200600798
Subject(s) - methacrylamide , polymer chemistry , hydrolysis , polymerization , aqueous solution , polymer , chemistry , radical polymerization , lower critical solution temperature , organic chemistry , copolymer , acrylamide
Novel acid‐labile, thermoresponsive methacrylamide‐based (co)polymers with pendent ortho ester groups were prepared by free radical polymerization of N ‐(2‐methoxy‐1,3‐dioxan‐5‐yl) methacrylamide (NMM) and N ‐(2‐ethoxy‐1,3‐dioxan‐5‐yl)methacrylamide (NEM). These polymers are both thermoresponsive and acid‐sensitive in aqueous solution, which was proved by transmittance measurements, fluorescence, and 1 H NMR spectroscopy. The LCSTs of the (co)polymers were shifted to higher temperature by increasing the content of the more hydrophilic NMM units. All of these polymers can be hydrolyzed under acidic condition and the hydrolysis rate increased with the decrease in the pH value.