Premium
Microwave‐Promoted Esterification Reactions: Optimization and Scale‐Up
Author(s) -
Amore Kristen M.,
Leadbeater Nicholas E.
Publication year - 2007
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200600751
Subject(s) - microwave heating , microwave , scale (ratio) , process engineering , microwave chemistry , scale up , reaction conditions , process (computing) , combinatorial chemistry , nanotechnology , chemical engineering , microwave irradiation , chemistry , materials science , organic chemistry , biochemical engineering , computer science , catalysis , physics , engineering , telecommunications , classical mechanics , quantum mechanics , operating system
Microwave heating is becoming a widely accepted tool for synthetic chemists. While many reactions have been performed on a small scale using microwave heating, few have been further developed into larger‐scale syntheses. Here, a microwave‐promoted esterification reaction protocol is presented. The apparatus used allows for the removal of water generated during the course of the reaction and as a result the process can be driven toward completion. Reactions have been run on scales up to 3 mol.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom