Premium
Surface‐Imprinted, Thermosensitive, Core‐Shell Nanosphere for Molecular Recognition
Author(s) -
Ko Du Young,
Lee Hwa Jeong,
Jeong Byeongmoon
Publication year - 2006
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200600259
Subject(s) - shell (structure) , materials science , core (optical fiber) , chemical engineering , nanotechnology , composite material , engineering
Summary: The D ‐glucose imprinted core‐shell nanosphere with an average size of ≈60 to 80 nm showed a significant preference for the binding of D ‐glucose than the non‐imprinted core‐shell nanosphere. Depending on temperature, the binding site in the shell with N ‐isopropylacrylamide oligomer underwent a significant change in binding affinity. In addition, the D ‐glucose imprinted core‐shell nanosphere showed a two times higher affinity for D ‐glucose than L ‐glucose, suggesting chiral recognition of the binding site. The core‐shell nanosphere reported here is a good biomimetic model system with a well‐defined morphology, high surface area, and variable binding affinity through a change in temperature.D ‐glucose imprinted core‐shell nanospheres showed excellent binding over the non‐imprinted core‐shell nanosphere.