Premium
Preparation of 5‐Fluorouracil‐Poly( L ‐lactide) Microparticles Using Solution‐Enhanced Dispersion by Supercritical CO 2
Author(s) -
Chen AiZheng,
Pu XiMing,
Kang YunQing,
Liao Li,
Yao YaDong,
Yin GuangFu
Publication year - 2006
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200600221
Subject(s) - scanning electron microscope , particle size , supercritical fluid , materials science , microparticle , dichloromethane , chemical engineering , supercritical carbon dioxide , lactide , particle size distribution , nuclear chemistry , copolymer , chemistry , polymer , composite material , organic chemistry , solvent , engineering
Summary: 5‐Fluorouracil‐poly( L ‐lactide) (5‐Fu‐PLLA) microparticles have been prepared by an SEDS process. First, the 5‐Fu is successfully micronized and is then used to produce the 5‐Fu‐PLLA microparticles. The 5‐Fu‐PLLA microparticles synthesized by the SEDS process exhibit a rather spherical shape and a narrow particle size distribution, where it ranges from 615 to 1 990 nm, with a mean particle size of 980 nm. The dichloromethane residue in the 5‐Fu‐PLLA microparticles without any further treatment is 46 ppm. The average drug load and encapsulation efficiency of the 5‐Fu‐PLLA microparticles are 3.05 and 17.8%, respectively. The rate of drug release from the 5‐Fu‐PLLA microparticles shows mainly first‐order kinetics.Scanning electron spectroscopy image of 5‐Fu‐PLLA microparticles.