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Nanogel‐Templated Mineralization: Polymer‐Calcium Phosphate Hybrid Nanomaterials
Author(s) -
Sugawara Ayae,
Yamane Setsuko,
Akiyoshi Kazunari
Publication year - 2006
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200500778
Subject(s) - nanogel , nanomaterials , nanoparticle , chemical engineering , materials science , liposome , polymer , calcium , phosphate , nanocomposite , drug delivery , nanotechnology , chemistry , organic chemistry , composite material , metallurgy , engineering
Summary: We report novel organic‐inorganic hybrid nanomaterials that consist of polymer hydrogel nanoparticles (nanogels) and calcium phosphate. Hybrid nanoparticles that measure ca. 40 nm are synthesized from a dilute solution of hydroxyapatite using nanogels as templates for calcium phosphate mineralization. These nanoparticles show a narrow size distribution and high colloidal stability. Nanogel‐adsorbed liposomes act as templates for hierarchical hybrid nanostructures. These nanohybrids can potentially be used as biocompatible drug carriers with controlled‐release properties.TEM images of calcium phosphate nanoparticles formed in the presence of CHP nanogels (0.5 mg · mL −1 ) (left) and nanogel‐liposomes (CHP 0.05 mg · mL −1 , DPPC 0.08 mg · mL −1 )(right).