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Linear Azo Polymer Containing Conjugated 5,5′‐Azodisalicylic Acid Segments in the Main Chain: Synthesis, Characterization, and Degradation
Author(s) -
Lai Junying,
Wang LiQun,
Tu Kehua,
Zhao Changsheng,
Sun Weilin
Publication year - 2005
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200500550
Subject(s) - copolymer , hydrolysis , biodegradation , ethylene oxide , polymer chemistry , polymer , materials science , chemistry , organic chemistry
Summary: Copolymers of poly(ethylene oxide) (PEO) and 5,5′‐azodisalicylic acid (Olsalazine, OLZ) were synthesized and evaluated by hydrolysis and in‐vitro biodegradation with azoreductase. It was found that changing the molecular weight of the PEO blocks affected the loading ratio of OLZ, and resulted in significant differences in the hydration and degradability of the copolymers. These novel azo‐containing copolymers can be used in colon‐specific drug delivery.Release of 5‐ASA from OLZ and PEO‐OLZ copolymers incubated with rat cecum content in the presence of benzyl viologen and α ‐ D ‐glucose.