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Saccharide Sensing Based on Saccharide‐Induced Conformational Changes in Fluorescent Boronic Acid Polymers
Author(s) -
Kanekiyo Yasumasa,
Sato Hiroaki,
Tao Hiroaki
Publication year - 2005
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200500423
Subject(s) - boronic acid , fluorescence , monomer , copolymer , chemistry , conformational change , polymer , excimer , polymer chemistry , combinatorial chemistry , organic chemistry , stereochemistry , physics , quantum mechanics
Summary: A novel fluorometric saccharide detection strategy has been established by utilizing saccharide‐induced conformational changes in copolymers containing boronic acid and fluorescent units. The polymer chain changes its conformation due to an alteration of the charge state induced by binding with saccharides. The conformational changes are conveniently detected by monitoring excimer to monomer intensity ratio in the fluorescence spectra. Thus, the present strategy would be a promising way for the creation of highly selective and sensitive saccharide‐sensing systems.Saccharide‐induced conformational change in copolymers containing boronic acid units.