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Synthesis and Controlled Polymerisation of a Novel Gramicidin S Analogue
Author(s) -
Ayres Lee,
Grotenbreg Gijsbert M.,
van der Marel Gijsbert A.,
Overkleeft Herman S.,
Overhand Mark,
van Hest Jan C. M.
Publication year - 2005
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200500303
Subject(s) - monomer , gramicidin s , moiety , polymer chemistry , gramicidin , atom transfer radical polymerization , polymerization , polymer , methacrylate , materials science , chemistry , organic chemistry , membrane , biochemistry
Summary: The controlled polymerisation of a bulky, peptide‐based monomer was investigated. The cyclic β ‐sheet forming decapeptide gramicidin S was modified with a methacrylate handle and subsequently polymerised via atom transfer radical polymerisation (ATRP), to yield a well‐defined gramicidin‐S‐containing polymer. The secondary structure of the peptide moiety was retained within the resulting polymer, as indicated by IR spectroscopy. This is the first example of the use of ATRP to create a synthetic polymer with a cyclic peptide as a side chain.The gramicidin S based monomers synthesised here were then polymerised by ATRP.