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Thermosensitive Micelles Self‐Assembled by Novel N ‐Isopropylacrylamide Oligomer Grafted Polyphosphazene
Author(s) -
Zhang Jian Xiang,
Qiu Li Yan,
Zhu Kang Jie,
Jin Yi
Publication year - 2004
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200400180
Subject(s) - polyphosphazene , micelle , lower critical solution temperature , poly(n isopropylacrylamide) , polymer chemistry , oligomer , copolymer , dynamic light scattering , materials science , amphiphile , hydrodynamic radius , polymer , critical micelle concentration , aqueous solution , chemistry , organic chemistry , nanoparticle , nanotechnology , composite material
Summary: A novel thermosensitive amphiphilic copolymer of PNIPAm grafted polyphosphazene (PNIPAm‐ g ‐PPP) has been synthesized through a co‐substitution reaction of poly(dichlorophosphazene) with amino terminated NIPAm oligomer and glycine ethyl ester (GlyEt). The polymer obtained had a molar ratio of 1:5.25 PNIPAm to GlyEt and had a lower critical solution temperature (LCST) near 30 °C. The formation of polymeric micelles was confirmed by fluorescence, dynamic light scattering and transmission electron microscopy measurements.The structure and formation of thermosensitive micelles of poly( N ‐isopropylacrylamide) grafted polyphosphazenes synthesized here.