Atom Transfer Radical Polymerization with Polypeptide Initiators: A General Approach to Block Copolymers of Sequence‐Defined Polypeptides and Synthetic Polymers | Zendy

Rettig Hartmut | Zendy; Krause Eberhard | Zendy; Börner Hans G. | Zendy

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Atom Transfer Radical Polymerization with Polypeptide Initiators: A General Approach to Block Copolymers of Sequence‐Defined Polypeptides and Synthetic Polymers

Author(s) -

Rettig Hartmut,

Krause Eberhard,

Börner Hans G.

Publication year - 2004

Publication title -

macromolecular rapid communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.348

H-Index - 154

eISSN - 1521-3927

pISSN - 1022-1336

DOI - 10.1002/marc.200400140

Subject(s) - copolymer , oligopeptide , atom transfer radical polymerization , polymer chemistry , acrylate , polymerization , polymer , materials science , radical polymerization , chemistry , peptide , biochemistry , composite material

Summary: A novel two‐step polymerization strategy allowing the integration of sequence‐defined oligopeptides into synthetic polymers has been demonstrated by the successful synthesis of an oligopeptide‐ block ‐poly( n ‐butyl acrylate) copolymer. The approach utilizes a solid‐phase supported synthesis of an oligopeptide macroinitiator (SPPS) followed by solution‐phase atom transfer radical polymerization (ATRP) initiated by the oligopeptide macroinitiator. The resulting block copolymer exhibited a low $\overline M _{\rm w} /\overline M _{\rm n}$ (1.19) and a controllable $\overline M _{\rm n}$ .Poly( n ‐butyl acrylate)‐ block ‐oligopeptide.

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