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Thermosensitive PEGylated Polypeptides
Author(s) -
Cho Jang Young,
Sohn Youn Soo,
Gutowska Anna,
Jeong Byeongmoon
Publication year - 2004
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200300318
Subject(s) - ethylene glycol , lower critical solution temperature , aqueous solution , hydrodynamic radius , peg ratio , micelle , critical micelle concentration , materials science , polymer chemistry , cloud point , chemical engineering , chemistry , polymer , organic chemistry , copolymer , finance , economics , engineering
Summary: We report a thermosensitive polypeptide consisting of hydrophilic poly(ethylene glycol)s and hydrophobic phenyl alanine ethyl esters. It is soluble in most solvents and undergoes a micelle (radius ≈ 10 nm) to nanoparticle (radius ≈ 100 nm) transition in water as the temperature increases. The transition temperature could be controlled to between 30 and 40 °C by varying the number of poly(ethylene glycol) grafts. This system might be promising for advanced drug delivery.Measurement of the lower critical solution temperatures of PEG‐PP aqueous solutions (1.0 wt.‐%).