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Novel Polyelectrolyte Carboxymethyl Konjac Glucomannan–Chitosan Nanoparticles for Drug Delivery
Author(s) -
Du Jian,
Sun Rui,
Zhang Sheng,
Govender Thirumala,
Zhang LiFang,
Xiong ChengDong,
Peng YuXing
Publication year - 2004
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200300314
Subject(s) - polyelectrolyte , chitosan , nanoparticle , drug delivery , glucomannan , aqueous solution , chemistry , chemical engineering , drug carrier , materials science , nanotechnology , organic chemistry , polymer , biochemistry , engineering
Summary: Carboxymethyl Konjac Glucomannan–Chitosan (CKGM‐CS) nanoparticles, which are well dispersed and stable in aqueous solution, were spontaneously prepared under very mild conditions by polyelectrolyte complexation. Investigations of the physicochemical properties of these nanoparticles were undertaken. This study showed that the nanoparticulate system driven by complex formation has potential as an advanced drug‐delivery system for water‐soluble drugs.Preparation mechanism of CS–CKGM nanoparticles.