Premium
The Formation of Biodegradable Polymeric Micelles from Newly Synthesized Poly(aspartic acid)‐ block ‐Polylactide AB‐Type Diblock Copolymers
Author(s) -
Arimura Hidetoshi,
Ohya Yuichi,
Ouchi Tatsuro
Publication year - 2004
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200300259
Subject(s) - copolymer , micelle , polymer chemistry , aspartic acid , monomer , polymerization , materials science , aqueous solution , lactide , dynamic light scattering , polymer , chemistry , organic chemistry , amino acid , nanoparticle , nanotechnology , composite material , biochemistry
Abstract Summary: A poly(aspartic acid)‐ block ‐polylactide (PAsp‐ block ‐PLA) diblock copolymer was synthesized through the polymerization of β ‐benzyl‐ L ‐aspartate‐ N ‐carboxyanhydride [Asp(OBzl)‐NCA] with amino‐terminating polylactide (NH 2 ‐PLA) as a macroinitiator. The chain length of the PAsp segment could be easily controlled by changing the monomer/initiator ratio. Dynamic light scattering measurements of PAsp‐ block ‐PLA aqueous solutions revealed the formation of polymeric micelles. Changes in the micelles as a function of pH were investigated.The structure and formation of micelles of the poly(aspartic acid)‐ block ‐polylactide (PAsp‐ block ‐PLA) diblock copolymers synthesized here.