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A Peptide‐Cyclodextrin Hybrid System Capable of Detecting Guest Molecules Utilizing Fluorescence Resonance Energy Transfer
Author(s) -
Yana Dewi,
Takahashi Tsuyoshi,
Mihara Hisakazu,
Ueno Akihiko
Publication year - 2004
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200300099
Subject(s) - förster resonance energy transfer , fluorescein , peptide , cyclodextrin , fluorescence , chemistry , molecule , quenching (fluorescence) , side chain , coumarin , photochemistry , combinatorial chemistry , organic chemistry , biochemistry , polymer , physics , quantum mechanics
Summary: A cyclodextrin‐peptide hybrid bearing coumarin and fluorescein on the peptide side chain has been designed and synthesized as a novel chemosensor molecule utilizing fluorescence resonance energy transfer (FRET). Inclusion of coumarin into β ‐cyclodextrin protects this system against fluorescent quenching, so that FRET occurs though donor and acceptor moieties nearby. FRET is diminished upon the addition of various guest compounds, suggesting that this system is useful for detecting molecules in aqueous solution.A cyclodextrin‐peptide hybrid bearing coumarin and fluorescein on the peptide side chain.