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Encapsulation of Bovine Serum Albumin in Temperature‐Programmed “Shell‐in‐Shell” Structures
Author(s) -
Jo YunSuk,
Kim DoKyung,
Jeong YoungKeun,
Kim KyungJa,
Muhammed Mamoun
Publication year - 2003
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.200300059
Subject(s) - ethylene glycol , differential scanning calorimetry , bovine serum albumin , materials science , shell (structure) , peg ratio , emulsion , polymer chemistry , nanoparticle , chemical engineering , spectroscopy , aqueous solution , micrograph , chemistry , nanotechnology , composite material , chromatography , organic chemistry , scanning electron microscope , physics , thermodynamics , finance , quantum mechanics , engineering , economics
A novel approach to load a hydrophilic bovine serum albumin into drug carriers was proposed in terms of temperature‐programmed “shell‐in‐shell” structures, which were fabricated with poly( N ‐isopropylacrylamide), poly(lactide), poly(ethylene glycol), and Au nanoparticles. Spherically well‐defined “shell‐in‐shell” structures were constructed by a modified‐double‐emulsion method (MDEM). The lower critical solubility temperature of the structures was manipulated to 36.4 °C which was confirmed by UV/Vis spectroscopy and DSC (Differential Scanning Calorimetry).TEM image of the Au@PLLA‐PEG@PNIPAAm‐PDLA structure.