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Doublestimuli‐responsive degradable hydrogels for drug delivery: Interpenetrating polymer networks composed of oligopeptide‐terminated poly(ethylene glycol) and dextran
Author(s) -
Kurisawa Motoichi,
Terano Minoru,
Yui Nobuhiko
Publication year - 1995
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.1995.030160905
Subject(s) - self healing hydrogels , dextran , ethylene glycol , oligopeptide , drug delivery , polymer chemistry , polymer , materials science , peg ratio , interpenetrating polymer network , chemistry , chemical engineering , polymer science , nanotechnology , organic chemistry , peptide , biochemistry , engineering , finance , economics
Biodegradable hydrogels composed of oligopeptide‐terminated poly(ethylene glycol) (PEG) and dextran with interpenetrating polymer network (IPN) structure were proposed as a novel substrate for multistimuli‐responsive drug delivery. IPN‐structured hydrogels were synthesized by sequential crosslinking reactions of N ‐methacryloyl‐glycilglycilglycil‐terminated PEG and dextran. In vitro degradation of the IPN‐structured hydrogels was examined using papain and dextranase as model enzymes for hydrolyzing the oligopeptide and the dextran. Specific degradation in the presence of papain and dextranase was observed in the IPN‐structured hydrogel with a particular composition of PEG and dextran, whereas this hydrogel was not degraded by one of the two enzymes.